PC Biotin-PEG3-alkyne( —— )

Catalog No. M33453 CAS No. 1869922-24-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

PC Biotin-PEG3-alkyne
Note

Research use only, not for human use.
Brief Description

PC Biotin-PEG3-alkyne is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).
Description

PC Biotin-PEG3-alkyne is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). PC Biotin-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
In Vivo

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Synonyms

——
Pathway

Antibody Drug Conjugates (ADC)
Target

ADCs Linker/Click Chemistry
Recptor

ADC Linker
Research Area

——
Indication

——

CAS Number

1869922-24-6
Formula Weight

780.89
Molecular Formula

C35H52N6O12S
Purity

>98% (HPLC)
Solubility

——
SMILES

C(CCCC(NCCOCCOCCOCCNC(CCCOC1=C(OC)C=C(C(OC(NCC#C)=O)C)C(N(=O)=O)=C1)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]
Chemical Name

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1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.?

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